Synthesis of Secondary Phosphine Oxides by Substitution at Phosphorus by Grignard Reagents

Author(s): Anna Tripolszky , Gyorgy Keglevich* .

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 5 , 2018

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Abstract:

Secondary phosphine oxides (SPOs) are important starting materials in organophosphorus syntheses, and may be the ligands in transition metal complexes. SPOs are obtained from phosphorus trichloride via double substitution by a Grignard reagent followed by hydrolysis, or from dialkyl phosphites by reaction with two equivalents of a Grignard reagent. The preparation of SPOs with two different substituents is of special importance. This minireview gives useful hints for the synthesis of a variety of SPOs that are useful intermediates.

Keywords: Dialkyl phosphites, grignard reagents, P(III)-chlorides, secondary phosphine oxides, substitution, ligand.

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Article Details

VOLUME: 15
ISSUE: 5
Year: 2018
Page: [387 - 393]
Pages: 7
DOI: 10.2174/1570178615666171227144555

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