Title:Synthesis of Secondary Phosphine Oxides by Substitution at Phosphorus by Grignard Reagents
VOLUME: 15 ISSUE: 5
Author(s):Anna Tripolszky and Gyorgy Keglevich*
Affiliation:Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest
Keywords:Dialkyl phosphites, grignard reagents, P(III)-chlorides, secondary phosphine oxides, substitution, ligand.
Abstract:Secondary phosphine oxides (SPOs) are important starting materials in organophosphorus
syntheses, and may be the ligands in transition metal complexes. SPOs are obtained from phosphorus
trichloride via double substitution by a Grignard reagent followed by hydrolysis, or from dialkyl
phosphites by reaction with two equivalents of a Grignard reagent. The preparation of SPOs with two
different substituents is of special importance. This minireview gives useful hints for the synthesis of a
variety of SPOs that are useful intermediates.
