Synthesis of 3-(7-Methylbenzo[d]oxazol-4-yl) Butanoic Acid: A Precursor of (+)-seco-Pseudopteroxazole and (+)-Pseudopteroxazole

Author(s): Aurelio Ortiz*, Pedro Ramírez, Jacqueline Jiménez, Angel Mendoza, Estibaliz Sansinenea.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 12 , 2018

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Graphical Abstract:


A novel synthesis of 3-(7-methylbenzo[d]oxazol-4-yl) butanoic acid as a possible precursor of (+)-seco-pseudopteroxazole and (+)-pseudopteroxazole is presented. This synthesis was performed from m-cresol where a Fries rearrangement, a nitration reaction and an olefination reaction were the key reactions to achieve the synthesis of 3-(7-methylbenzo[d]oxazol-4-yl) butanoic acid.

Keywords: (+)-seco-pseudopteroxazole, (+)-pseudopteroxazole, antituberculotic, Mycobacterium tuberculosis, nitration reaction, olefination.

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Article Details

Year: 2018
Page: [1030 - 1036]
Pages: 7
DOI: 10.2174/1570178615666171227142301
Price: $65

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