In this work, two new prolinamides with isosteviol skeleton were synthesized and used as
chiral catalysts for the asymmetric aldol reaction. Solvent effects, catalyst loading, substrate scope and
the influence of water on the reaction were investigated. With only 5 mol % loading, the synthesized
catalysts showed excellent activity (up to 98% yield) and good stereoselectivity (up to 87:13 dr, 90%
ee) for the direct aldol reaction of cyclohexanone and substituted benzaldehydes at room temperature.
Keywords: Aldol reaction, asymmetric catalysis, isosteviol, organocatalyst, prolinamide, synthesis.
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