Formulation and Evaluation of Novel Solid Lipid Microparticles for the Sustained Release of Ofloxacin

Author(s): Aashima Hooda*, M. Sradhanjali, Popsy.

Journal Name: Pharmaceutical Nanotechnology

Volume 5 , Issue 4 , 2017

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Graphical Abstract:


Objective: The aim of this study was to prepare solid lipid microparticles (SLM) with incorporated ofloxacin, suitable for oral delivery.

Methods: Ofloxacin-loaded SLM were prepared using stearic acid and chloroform as lipid matrix and Tween-80 as surfactant, by high shear homogenization technique and followed by lyophilization. The physiochemical characterization of SLMs were investigated by scanning electron microscopy, transmission electron microscopy, zeta potential, zone of inhibition, in-vitro study, ex-vivo study and stability study.

Results: The result demonstrated that the entrapment efficiency, particle size and zeta potential of microparticles were 86.02%, 203.7nm and -32.68mv, respectively. The in-vitro and ex-vivo studies showed sustained release of drug from formulation.

Conclusion: These results indicate that SLM might be a promising delivery system to enhance the pharmacological activity of ofloxacin.

Keywords: High shear homogenization technique, ofloxacin, solid lipid microparticles, stearic acid, Tween-80.

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Article Details

Year: 2017
Page: [329 - 341]
Pages: 13
DOI: 10.2174/2211738506666171226121720
Price: $58

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