Aim and Objective: Cancer is one of the serious diseases that cause several human deaths
every year. Up to now, we have spent lots of time and money to investigate this disease, thereby
designing effective treatments. Previous studies mainly focus on studying genetic background of
different subtypes of cancer and neglect another important factor, i.e. environmental factor.
Carcinogenic chemical is one of the types of environmental factor; the exposure of such chemical
may definitely initiate and promote the tumorigenesis. In this study, we tried to partly describe the
differences between carcinogenic and non-carcinogenic chemicals using gene ontology (GO) terms
and KEGG pathways.
Material and Methods: The carcinogenic and non-carcinogenic chemicals that were retrieved from
Carcinogenic Potency Database (CPDB) were encoded into numeric vectors using the enrichment
theories of GO terms and KEGG pathways. Then, the minimal redundancy maximal relevance
(mRMR) method was adopted to analyze all the features, resulting in some important GO terms and
Results and Conclusion: The extensive analysis of the identified GO terms and KEGG pathways
indicates that they all play roles during tumorigenesis, inducing that they can be the key indicator for
the identification of carcinogenic chemicals.