Anti-Angiogenesis Drug Discovery and Development

Anti-Angiogenesis Drug Discovery and Development

Volume: 4

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of ...
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Cancerous Tumor Growth, Driven by Hypoxia Induced Angiogenesis is Slowed by Brief Daily EMF Therapy

Pp. 19-33 (15)

Ivan Cameron

Abstract

As cancerous tumors grow their continued increase in cancer cell number becomes dependent on an increased blood supply from the surrounding host non-tumor tissue. Tumor cancer cells furthest from the host blood supply become hypoxic and without an increased blood supply these cancer cells become necrotic and die. The cancer cells that become hypoxic are triggered to synthesize hypoxia inducible factor (HIF) and vascular endothelial growth factor (VEGF) that is released from the hypoxic cell to stimulate a major increase in sprouting of endothelial cells. Thus neoangiogenesis in the tumor is apparently hypoxia driven in tumors.

Our research group found that a brief daily therapeutic electromagnetic field exposure (TEMF) slowed breast cancer tumor growth in syngenetic mice. The optimal TEMF exposure dose for retardation of tumors growth and angiogenesis without harmful side effects was a 120 Hz semi-sine wave given at 15 mT for 10 minutes a day. This TEMF therapy gave the maximum antiangiogenic effect with no noticeable side effects. Although this TEMF slowed tumor growth it did not cause the tumors to shrink in size.

An experiment was done to find out if combining two different therapies, one targeting angiogenesis (TEMF) and the other targeting killing of rapidly dividing cells (gamma irradiation-IR), might have an additive tumor inhibitive effect. In short TEMF, combined with IR proved to have a significant additive tumor inhibiting effect and TEMF was judged to be a safe effective adjunct to IR therapy.

Keywords:

Angiogenesis, Antiangiogenic therapy, Blood vessels, Blood vessel marker CD 31, Breast cancer, Electromagnetic field therapy, Endothelial cells, Gamma irradiation, Hypoxia, Hypoxia inducible factor, Metastasis, Morphometric analysis, Tumorous cancer, Tumor growth, Tumor structure.

Affiliation:

Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio 7703, Floyd Curl Drive San Antonio, TX 78229-3900, USA.