Abstract
Degenerative diseases are becoming more common with increasing life expectancy of the human population. The 20th century faced a progressive demographic change in the industrialized world, followed by identical trends in population aging in Asia, Africa, and Middle and South America. A significant increase in chronic age-dependent disorders will soon cause important challenges for several countries. Age-related pathologies are commonly seen in elderly patients. More than 40% of adults over 60 years old present a combination of risk factors, described as metabolic syndrome, which significantly increases the tendency for developing degenerative diseases, and some types of cancers. Among these, Parkinson's, Alzheimer's and cardiovascular diseases are on the top of the list. The discovery of effective cardio- and neuroprotective alternative therapeutics that decrease or block disease's progression at early stages, is the main goal of research groups working in the field. A wide range of different substituted coumarins, and the pharmacological properties they may display, are trend topics because of their synthetic accessibility, as well as their abundance in plants and other naturally-occurring products. These heterocyclic compounds play an important role in a variety of areas, but stand out in the field of Medicinal Chemistry. This review provides an overview of the last five years about the potential of coumarins as modulators of several physiological mechanisms involved in age-related pathologies.
Keywords: Coumarins, Age-related diseases, Cardiovascular diseases, Neurodegenerative diseases, Alzheimer's metabolic syndrome.
Current Topics in Medicinal Chemistry
Title:Coumarins as Promising Scaffold for the Treatment of Age-related Diseases – An Overview of the Last Five Years
Volume: 17 Issue: 29
Author(s): Giovanna Lucia Delogu and Maria Joao Matos*
Affiliation:
- Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela,Spain
Keywords: Coumarins, Age-related diseases, Cardiovascular diseases, Neurodegenerative diseases, Alzheimer's metabolic syndrome.
Abstract: Degenerative diseases are becoming more common with increasing life expectancy of the human population. The 20th century faced a progressive demographic change in the industrialized world, followed by identical trends in population aging in Asia, Africa, and Middle and South America. A significant increase in chronic age-dependent disorders will soon cause important challenges for several countries. Age-related pathologies are commonly seen in elderly patients. More than 40% of adults over 60 years old present a combination of risk factors, described as metabolic syndrome, which significantly increases the tendency for developing degenerative diseases, and some types of cancers. Among these, Parkinson's, Alzheimer's and cardiovascular diseases are on the top of the list. The discovery of effective cardio- and neuroprotective alternative therapeutics that decrease or block disease's progression at early stages, is the main goal of research groups working in the field. A wide range of different substituted coumarins, and the pharmacological properties they may display, are trend topics because of their synthetic accessibility, as well as their abundance in plants and other naturally-occurring products. These heterocyclic compounds play an important role in a variety of areas, but stand out in the field of Medicinal Chemistry. This review provides an overview of the last five years about the potential of coumarins as modulators of several physiological mechanisms involved in age-related pathologies.
Export Options
About this article
Cite this article as:
Delogu Lucia Giovanna and Matos Joao Maria *, Coumarins as Promising Scaffold for the Treatment of Age-related Diseases – An Overview of the Last Five Years, Current Topics in Medicinal Chemistry 2017; 17 (29) . https://dx.doi.org/10.2174/1568026618666171215094029
DOI https://dx.doi.org/10.2174/1568026618666171215094029 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Foreword
Current Nutrition & Food Science Omega-3 Polyunsaturated Fatty Acids: Their Potential Role in Blood Pressure Prevention and Management
Current Vascular Pharmacology Dasabuvir: A Non-Nucleoside Inhibitor of NS5B for the Treatment of Hepatitis C Virus Infection
Reviews on Recent Clinical Trials Obesity and Cardioprotection
Current Medicinal Chemistry Oral IIa and Xa Inhibitors for Prevention of Stroke in Atrial Fibrillation: Clinical Studies and Regulatory Considerations
Current Clinical Pharmacology The Epidemiology of Cardiovascular Disease in Adults with Type 1 Diabetes
Current Diabetes Reviews Aspirin: from a Historical Perspective
Recent Patents on Cardiovascular Drug Discovery Biological Ageing, Inflammation and Nutrition: How Might They Impact on Systemic Sclerosis?
Current Aging Science Coffee and Depression: A Short Review of Literature
Current Pharmaceutical Design Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets
Current Protein & Peptide Science Increased Content of Free Phenolic Compounds and Antioxidant Activity of Grape Pomace Cultivated with Three Different β-glucosidase Fungi Producers
Current Bioactive Compounds SARS: Understanding the Virus and Development of Rational Therapy
Current Molecular Medicine An Insight into the Recent Diabetes Trials: What is the Best Approach to Prevent Macrovascular and Microvascular Complications?
Current Diabetes Reviews Assessing Myocardial Metabolism with Hybrid PET Imaging: Instrumentation, Concepts, and Workflows
Current Pharmaceutical Design Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety
CNS & Neurological Disorders - Drug Targets Nutrient Content of Lettuce and its Improvement
Current Nutrition & Food Science Adult Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise
CNS & Neurological Disorders - Drug Targets Acute Coronary Syndromes in Patients with Atrial Fibrillation and Heart Failure. Could Novel Oral Anticoagulants be the Solution of the Optimal Antithrombotic Therapy Puzzle?
Cardiovascular & Hematological Agents in Medicinal Chemistry Atypical Presentation Of Anti-Retroviral Therapy Induced Lactic Acidosis as Acute Right Ventricular Failure And Severe Pulmonary Hypertension
New Emirates Medical Journal The Neuroprotective Role of Repetitive Transcranial Magnetic Stimulation (rTMS) for Neurodegenerative Diseases: A Short Review on Experimental Studies
Mini-Reviews in Medicinal Chemistry