Degenerative diseases are becoming more common with increasing life expectancy of the
human population. The 20th century faced a progressive demographic change in the industrialized world,
followed by identical trends in population aging in Asia, Africa, and Middle and South America. A significant
increase in chronic age-dependent disorders will soon cause important challenges for several
countries. Age-related pathologies are commonly seen in elderly patients. More than 40% of adults over
60 years old present a combination of risk factors, described as metabolic syndrome, which significantly
increases the tendency for developing degenerative diseases, and some types of cancers. Among these,
Parkinson's, Alzheimer's and cardiovascular diseases are on the top of the list. The discovery of effective
cardio- and neuroprotective alternative therapeutics that decrease or block disease's progression at
early stages, is the main goal of research groups working in the field. A wide range of different substituted
coumarins, and the pharmacological properties they may display, are trend topics because of their
synthetic accessibility, as well as their abundance in plants and other naturally-occurring products.
These heterocyclic compounds play an important role in a variety of areas, but stand out in the field of
Medicinal Chemistry. This review provides an overview of the last five years about the potential of
coumarins as modulators of several physiological mechanisms involved in age-related pathologies.