Whole Lung Lavage for Pulmonary Alveolar Proteinosis
Pp. 310-318 (9)
Suhaib Khan and Ahmed Awab
Pulmonary Alveolar Proteinosis (PAP) is a rare disease characterized by the
accumulation of proteinaceous material in the alveoli, resulting in progressive
hypoxemia and functional limitation. Whole lung lavage under general anesthesia with
normal saline has become established as a safe and effective treatment for PAP. The
technique varies slightly from institution to institution, but essentially involves the
instillation and removal of 500-1000ml aliquots of normal saline from one lung at a
time, which removes the offending material from the alveoli. There is often significant
functional improvement within weeks that can persist for months or years. Repeat
lavage can be done when symptoms return.
Alveolar proteinosis, Lung Lavage, Pulmonary alveolar proteinosis,
Whole lung lavage.
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.