Background: Aminopyrimidines represent very important class of
functionalized heterocycles having wide applications in organic and medicinal chemistry.
Recently, considerable attention has been paid on exploration of aminopyrimidines in
pot, atom and step economic multicomponent reactions.
Objective: The main objective of this review is to give an overview on the recent
applications of aminopyrimidines in multicomponent reactions.
Method: In this review, we have broadly divided all the aminopyrimidine based multicomponent
reactions into two major categories leading to (i) cyclic pyrimidine fused derivatives
and (ii) acyclic substituted pyrimidine derivatives as products. Again reactions
forming fused heterocycles from the aminopyrimidine based multicomponent reactions have been sub
categorized as MCRs providing five membered, six membered and spirofused products. Similarly, MCRs
providing acyclic substituted products have been subdivided into two categories involving only C-nucleophilic
site of the aminopyrimidine to give C-substituted aminopyrimidines and using N-nucleophilic site to provide
N-substituted acyclic products.
Conclusion: We have shown the various reactivity patterns of aminopyrimidines in multicomponent reactions
and up-to-date literature on aminopyrimidine based MCRs has been systematically presented. Finally,
aminopyrimidines are considered as promising substrates in MCRs for the synthesis of diverse heterocycles.
We hope that this review will serve as a stimulus for ongoing research in the field of MCRs and heterocyclic