CRISPR-Cas in Medicinal Chemistry: Applications and Regulatory Concerns

Author(s): Aliuska Duardo-Sanchez*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 30 , 2017

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Graphical Abstract:


A rapid search in scientific publication’s databases shows how the use of CRISPR-Cas genome editions’ technique has considerably expanded, and its growing importance, in modern molecular biology. Just in pub-med platform, the search of the term gives more than 3000 results. Specifically, in Drug Discovery, Medicinal Chemistry and Chemical Biology in general CRISPR method may have multiple applications. Some of these applications are: resistance-selection studies of antimalarial lead organic compounds; investigation of druggability; development of animal models for chemical compounds testing, etc. In this paper, we offer a review of the most relevant scientific literature illustrated with specific examples of application of CRISPR technique to medicinal chemistry and chemical biology. We also present a general overview of the main legal and ethical trends regarding this method of genome editing.

Keywords: CRISPR-Cas, Drug discovery, Gene editing legal issues.

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Article Details

Year: 2017
Page: [3308 - 3315]
Pages: 8
DOI: 10.2174/1568026618666171211151142
Price: $58

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PDF: 28