Frontiers in Clinical Drug Research: HIV

Frontiers in Clinical Drug Research: HIV

Volume: 4

Indexed in: Scopus, EBSCO.

Frontiers in Clinical Drug Research – HIV is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment ...
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Potential Magnetic Nanotherapeutics for Management of neuroAIDS

Pp. 34-60 (27)

Vidya Sagar, Arti Vashist and Madhavan Nair

Abstract

The human immunodeficiency virus (HIV) infection into the brain induces neurotoxicity and neuropathology which are collectively termed as the neuroAIDS. Brain delivery of therapeutic molecules continues to be the greatest challenge, primarily because of the tightly-junctioned blood-brain barrier (BBB). Several nanovehicles are under intensive examination for delivering drugs across the BBB. Magnetic nanoparticles (MNPs) possess advantages over their counterparts because of their potential utilization for non-invasive brain targeting using external magnetic force. MNPs can be physicochemically modulated for engineering smart drug delivery carrier as well. Nonetheless, rigorous research is required to fix associated shortcomings of MNPs before their real-time application.

Keywords:

Blood-Brain Barrier, HIV, Magnetic Nanocarriers, NeuroAIDS, Neuropathogenesis, Synaptic plasticity.

Affiliation:

Center for Personalized Nanomedicine/Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida - 33199, USA.