Background: Until recently, one of the main reasons for mortality has been infectious diseases,
and bacteria that are drug-resistant have emerged as a result of the wide application, as well as the
misuse of antibacterial medications. Having multidrug-resistance, bacteria present a great problem for
the efficient management of bacterial infections and this challenge has resulted in the creation of other
means of dealing with bacterial diseases. Of late, metallic nanoparticles (NPs), employed as antibacterial
agents, have the potential for use against resistance to bacterial drugs.
Objective: The mechanisms of bacterial resistance are described in this review and this is followed by
an outline of the features and uses of metallic NPs as antibiotic agents to address bacteria that are antibiotic-
sensitive and resistant. Additionally, a general impression of metallic NPs as antibiofilm bactericidal
agents is presented.
Conclusion: Biofilms and bacterial strains that are resistant to antibiotics present a grave public health
challenge and this has enhanced the need to develop new bactericidal agents. Therefore, nanomaterials
are considered as a potential platform for managing bacterial infections.