Vitamin B12 production by using propionibacteria and enriching food to produce functional
foods is an important subject for researches. Some microorganisms have the potential to produce a
wide range of components that are health promoting for human. Among them Propionibacteria has
been identified as an effective producer of vitamin B12 and anti-microbial compounds such as propionic
acid for decades. In this study at first, the structure, health beneficial effects and properties of vitamin
B12 as well as scaled up production of vitamin are mentioned. Then biotechnological strategy is
described as a solution to overcome vitamin deficiency and production of functional food. Finally, the
specification of propionibacteria and its growth condition as well as bacterium ability to produce some
other interesting metabolite in human food as byproduct are discussed.
Keywords: Biosynthesis, functional food, health effects, propionibacteria, vitamin B12, anti-microbial compounds.
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