Abstract
Background and Objective: Systemic lupus erythematosus (SLE) is a diverse autoimmune disorder, evoked in response to self-immune system that leads to immune complex depositions and organ damage. The exact mechanism of SLE pathogenesis is still unclear but certain genetic and environmental factors have been suggested that could influence its pathogenesis.
Discussion: The modulation in B- and T- cell responses and genetic variations could lead to abnormal lymphocyte functions and the production of antibodies against the indigenous proteins and the immune complex depositions.
Conclusion: The present review highlights the various causatives of SLE, particularly the genetic alteration in B- and T-cell-related proteins. We have also delineated some of the available therapeutic strategies for the treatment of SLE.
Keywords: Cytokines, inflammation, interferons, polymorphism, pathogenesis, systemic lupus erythematosus.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:An Insight on the Pathogenesis and Treatment of Systemic Lupus Erythematosus
Volume: 18 Issue: 2
Author(s): Murtaza Ali, Chelapram K. Firoz, Nasimudeen R. Jabir, Mohd Rehan, Mohd S. Khan and Shams Tabrez*
Affiliation:
- King Fahd Medical Research Center, King Abdulaziz University, Jeddah,Saudi Arabia
Keywords: Cytokines, inflammation, interferons, polymorphism, pathogenesis, systemic lupus erythematosus.
Abstract: Background and Objective: Systemic lupus erythematosus (SLE) is a diverse autoimmune disorder, evoked in response to self-immune system that leads to immune complex depositions and organ damage. The exact mechanism of SLE pathogenesis is still unclear but certain genetic and environmental factors have been suggested that could influence its pathogenesis.
Discussion: The modulation in B- and T- cell responses and genetic variations could lead to abnormal lymphocyte functions and the production of antibodies against the indigenous proteins and the immune complex depositions.
Conclusion: The present review highlights the various causatives of SLE, particularly the genetic alteration in B- and T-cell-related proteins. We have also delineated some of the available therapeutic strategies for the treatment of SLE.
Export Options
About this article
Cite this article as:
Ali Murtaza , Firoz K. Chelapram, Jabir R. Nasimudeen , Rehan Mohd , Khan S. Mohd and Tabrez Shams *, An Insight on the Pathogenesis and Treatment of Systemic Lupus Erythematosus, Endocrine, Metabolic & Immune Disorders - Drug Targets 2018; 18 (2) . https://dx.doi.org/10.2174/1871530318666171207145003
DOI https://dx.doi.org/10.2174/1871530318666171207145003 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Growth Factors and Bone Formation in Osteoporosis: Roles for Fibroblast Growth Factor and Transforming Growth Factor Beta
Current Pharmaceutical Design Inhibitors of the TGF-β Superfamily and their Clinical Applications
Mini-Reviews in Medicinal Chemistry Graves Ophthalmopathy: A Review of Immunogenetics
Current Genomics Association of Neutrophil-Lymphocyte Ratio with Mild Cognitive Impairment in Elderly Chinese Adults: A Case-control Study
Current Alzheimer Research Gynecomastia in Infants, Children, and Adolescents
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Genetic Polymorphisms of Type-1 and Type-2 Inflammatory Cytokines in Ischaemic Stroke
Vascular Disease Prevention (Discontinued) The Corticotropin-Releasing Factor (CRF) Family of Neuropeptides in Inflammation: Potential Therapeutic Applications
Current Medicinal Chemistry Subject Index Volume 2
Medicinal Chemistry Intracellular Bioinorganic Chemistry and Cross Talk Among Different -Omics
Current Topics in Medicinal Chemistry A novel method for measuring TBAb activity in TSAb- and TBAb-positive serum
Endocrine, Metabolic & Immune Disorders - Drug Targets Role of Apoptosis in the Pathogenesis of Contrast Media-induced Nephropathy and Hints for its Possible Prevention by Drug Treatment
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Molecular Genetics and Biomarkers of Polyglutamine Diseases
Current Molecular Medicine HMG-CoA Reductase Inhibitors: Effects on Chronic Subacute Inflammation and Onset of Atherosclerosis Induced by Dietary Cholesterol
Current Drug Targets - Cardiovascular & Hematological Disorders Cancer Therapy Based on a Mechanism of Action for Controlling the Immune System and the Resulting Patent Portfolio
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Characteristics Other than the Diagnostic Criteria Associated with Metabolic Syndrome: An Overview
Current Vascular Pharmacology The Protein Profile of Buffalo Testis
Current Proteomics A Focus on Microfluidics and Nanotechnology Approaches for the Ultra Sensitive Detection of MicroRNA
MicroRNA Drugs and Foods for Chronic Subclinical Inflammation in Humans
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Role of AGEs-RAGE System in Cardiovascular Disease
Current Pharmaceutical Design mTOR in Growth and Protection of Hypertrophying Myocardium
Cardiovascular & Hematological Agents in Medicinal Chemistry