Background and Objective: Systemic lupus erythematosus (SLE) is a diverse autoimmune
disorder, evoked in response to self-immune system that leads to immune complex depositions and
organ damage. The exact mechanism of SLE pathogenesis is still unclear but certain genetic and environmental
factors have been suggested that could influence its pathogenesis.
Discussion: The modulation in B- and T- cell responses and genetic variations could lead to abnormal
lymphocyte functions and the production of antibodies against the indigenous proteins and the immune
Conclusion: The present review highlights the various causatives of SLE, particularly the genetic alteration
in B- and T-cell-related proteins. We have also delineated some of the available therapeutic
strategies for the treatment of SLE.
Keywords: Cytokines, inflammation, interferons, polymorphism, pathogenesis, systemic lupus erythematosus.
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