Background: The patients with schizophrenia are at increased risk for problems regarding
metabolic parameters due to their lifestyle and antipsychotic treatment.
Objective: In this study, we aimed to evaluate the levels of adiponectin, leptin, irisin in patients with
schizophrenia who were nondiabetic, nonobese and under antipsychotic treatment.
Method: 5 ml sample of venous blood was collected from each participant. Blood cells were separated
from the serum. The serum samples were stored in a -80°C freezer. Biochemical analyses were performed
on these samples. Adiponectin, leptin and irisin levels were measured by Enzyme Linked Immunosorbent
Results: The study included 88 subjects. Of them, 44 were patients with schizophrenia and 44 were
healthy controls. There were no statistically significant results when the c-reactive protein, adiponectin,
leptin and irisin levels were compared between the schizophrenia and the control group (p>0.05).
Conclusion: In our study, adiponectin, leptin and irisin levels in patients with schizophrenia did not
present a statistically significant difference from healthy controls. Therefore, there is a need for studies
including more participants to investigate the level of irisin in patients with schizophrenia.