Background: Research on natural bioactive compounds has increased exponentially over the
last decades. The discovery of new phytochemicals that possess pharmaceutical properties is useful in
the development of therapeutic alternatives. The nerolidol (3,7,11-trimetil-1,6,10-dodecatrien-3-ol or
3,7,11-trimetildodeca-1,6,10-trien-3-ol) has been extensively studied for its therapeutic potential because
of its pharmacological activities in the treatment of neurodegenerative diseases.
Method: All articles and patents regarding nerolidol and its pharmacological properties were revised,
focusing mainly on the important properties in the treatment of neurodegenerative diseases. A thorough
search in article databases (Science Direct, MEDLINE/PubMed, Scopus and Scielo) and patent database
(WIPO, EPO, ESPTO, LATIPAT and INPI) was performed over the course of this study.
Results: Several studies stood out for their relevance regarding the treatment of neurodegenerative diseases.
Nerolidol demonstrated anticholinesterasic, antioxidant, antinociceptive, anti-inflammatory and
anxiolytic activities, thus classifying it as a promising phytochemical for the development of therapeutic
Conclusion: Analysis suggested that nerolidol is a promising target for new drugs and treatment of neurodegenerative