Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population

Author(s): Naseem Akhter, Sajad A. Dar, Shilpi Chattopadhyay, Shafiul Haque, Razique Anwer, Mohd Wahid, Arshad Jawed, Mohtashim Lohani, Raju K. Mandal, N. K. Shukla, Yasir Abdul, Syed Akhtar Husain*.

Journal Name: Current Genomics

Volume 19 , Issue 5 , 2018

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Abstract:

Background: Genetic changes in p53 gene contribute to breast cancer susceptibility.

Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women.

Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence.

Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

Keywords: p53 codon72 SNP, Breast cancer, Indian populations, Case-control, Meta-analysis, p53 Arg72Pro polymorphism.

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Article Details

VOLUME: 19
ISSUE: 5
Year: 2018
Page: [395 - 410]
Pages: 16
DOI: 10.2174/1389202919666171205104137
Price: $58

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