Background: Aging is a natural part of human life. However, recent discoveries
indicate that pharmacological approaches used for the improvement and possibly, for
the delay of the aging process, might shed a new light on this topic. This might obviously
contribute to the extension of the active life of older people and maintenance of their
quality of life, which could consequently reduce both social and economic burden of each
country, especially the developed ones.
Objective: The purpose of this study is to explore pharmacological discoveries which may
help to the delay or improvement of the aging process. More specifically, the authors focus
on three anti-aging drugs candidates: metformin, rapamycin and resveratrol and one
anti-aging component NAD+ precursors whose randomized control trials on animals have
appeared to provide some efficacy in this respect and they seem to be promising in the aging
process of human beings.
Methods: This was done by conducting a literature review of available sources describing
the issue of aging process with special focus on those anti-aging drug candidates.
Results: The results of this study indicate that promising anti-aging candidates seem to be
metformin, especially as far as cardiovascular or cancer mortality is concerned, and
NAD+ precursors since they appear to promote better organ function, increased physical
resistance, disease resistance and prolonged life expectancy.
Conclusion: There is a call for more longitudinal clinical trials, which would prove the
efficacy of the promising anti-aging drugs candidates in humans.