Background: Cancer is one of the leading causes of morbidity and mortality worldwide.
Brain cancer is identified as one of the most formidable forms of cancer due to several hurdles posed
by the anatomy and physiology of the brain on the therapeutic strategies employed for treating brain
cancer. Poor prognosis and high relapse rate further aggravate the situation leading to the high mortality
rate in brain cancer.
Objective: The present review gives a brief insight on different aspects of brain cancer by elucidating
its types, causative factors, associated symptoms, diagnostic techniques, treatment strategies and limitations
of current treatment strategies. The review summarizes novel drug delivery based treatment
strategies for tumor targeting.
Methods: Conventional surgical or chemotherapy based strategies are less efficient for treating brain
cancer. Surgery is risky because extracting the tumors can permanently damage the brain and alter the
patient's ability to function. Sometimes, surgery cannot be performed because of the anatomical location
of the tumor which is beyond the reach or near to any vital region. Drug based therapy requires
heavy doses to cross the blood brain barrier leading to systemic toxicity. The review summarizes fifteen
different patented technologies for targeting the drug substance specifically to the tumor site in the
Result: Targeted drug delivery strategies serve as an efficient tool for treating brain cancer.
Conclusion: Novel strategies focused towards targeting drug substances specifically to brain tumor site
would increase the therapeutic efficiency and reduce the toxicity of chemotherapeutics.