Critical Role of IL-8 Targeting in Gliomas

Author(s): Marinos Kosmopoulos, Anthos Christofides, Dimitrios Drekolias, Phaedon D. Zavras, Antonios N. Gargalionis, Christina Piperi*.

Journal Name: Current Medicinal Chemistry

Volume 25 , Issue 17 , 2018

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Abstract:

Background: Glioma is a heterogeneous, highly complicated central nervous system (CNS) tumor with uncertain mechanism of initiation and progression, resulting in an unfavorable outcome. An extended network of cytokines is recognized as a major regulator of glioma pathogenesis, either promoting or inhibiting glioma progression based on their type and specificity. Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas.

Objective: The aim of the present review is to address the role of IL-8 in glioma pathogenesis focusing on the implicated molecular pathways as well as on its potential targeting for glioma therapy.

Methods and Results: PubMed-Medline, SCOPUS, and Google Scholar databases were searched for pre-clinical and clinical studies related to IL-8 implication in gliomagenesis and IL-8 targeting strategies for gliomas. Literature data indicate that IL-8 participates in glioma angiogenesis and cell migration and it can serve as a potential biomarker, for early diagnosis, follow-up and response to therapy.

Conclusion: Several promising approaches that target directly or indirectly IL-8 effects in gliomas are currently in progress while more-in-depth studies are needed to validate its biomarker role and elucidate the underlying molecular mechanisms.

Keywords: Glioma, IL-8, angiogenesis, migration, therapy, CNS tumor, cytokines.

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Article Details

VOLUME: 25
ISSUE: 17
Year: 2018
Page: [1954 - 1967]
Pages: 14
DOI: 10.2174/0929867325666171129125712
Price: $58

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