Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for α-
ketoamides has been developed by using secondary amines.
Methods: In the synthetic method, the targeted α-ketoamides were synthesized with the help of microwave
by reacting secondary amines and aryl methyl ketones in the presence of copper chloride and
Results: α-ketoamides were prepared in good yields (within 10mins) with the help of a microwave
irradiation. The reported protocol is ligand free and the yields of the derivatives were modest to
Conclusion: Microwave assisted technique will be a useful alternative method for the preparation of