Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects

Author(s): Dominik Szwajgier* , Ewa Baranowska-Wojcik , Kamila Borowiec .

Journal Name: Current Alzheimer Research

Volume 15 , Issue 6 , 2018

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Abstract:

Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement.

Keywords: Alzheimer's disease, amyloid β-peptide, cinnamic acid, benzoic acid, acetylcholinesterase, butyrylcholinesterase, cognition.

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Article Details

VOLUME: 15
ISSUE: 6
Year: 2018
Page: [531 - 543]
Pages: 13
DOI: 10.2174/1567205014666171128102557
Price: $58

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