Numerous authors have provided evidence regarding the beneficial effects of phenolic acids
and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors
of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the
structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of
amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning
the prevention and treatment of the cognitive enhancement.
Keywords: Alzheimer's disease, amyloid β-peptide, cinnamic acid, benzoic acid, acetylcholinesterase, butyrylcholinesterase,
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