Lupus Nephritis: Current Treatment Paradigm and Unmet Needs

Author(s): Steven P. Menez*, Basset El Essawy, Mohamed G. Atta.

Journal Name: Reviews on Recent Clinical Trials

Volume 13 , Issue 2 , 2018

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Abstract:

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by chronic inflammation, which can result in a multitude of systemic or organ-limited manifestations, including the skin, lungs, heart, and kidney. SLE nephritis is present in an average of 38% of patients at the time of diagnosis, and may occur as the initial presentation of disease with progression to End-Stage Renal Disease (ESRD) in roughly 10-20% of patients.

Methods: A review of the current literature was undertaken to investigate the evolution of treatment of SLE nephritis based on randomized trials and robust observational studies. We aimed to provide a timeline of the development of current induction and maintenance therapy, as well as the development of novel targeted therapies, all leading to current guidelines.

Results: Based on all available current data on standard of care therapies for SLE nephritis, there is at best a complete remission rate of 50-60%, and roughly 13-25% of patients experience periods of relapse during maintenance therapy for SLE nephritis. Therefore, the need for newer, targeted therapies has been the focus of many current, ongoing clinical trials.

Conclusion: Standard induction and maintenance therapies at present are anti-proliferative and nonspecific, that is, interfering with the process of autoantigen presentation and activation of autoreactive leukocytes. However, newer agents with specific T-cell, B-cell, or proteasome targets are currently being investigated.

Keywords: Chronic kidney disease, clinical trials, End-Stage Renal Disease (ESRD), immunosuppression, kidney biopsy, systemic lupus erythematosus.

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2018
Page: [105 - 113]
Pages: 9
DOI: 10.2174/1574887112666171123113200

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