Tocopherol and Tocotrienol: Therapeutic Potential in Animal Models of Stress

Title:Tocopherol and Tocotrienol: Therapeutic Potential in Animal Models of Stress

Volume: 19 Issue: 12

Author(s): Mohd Fahami Nur Azlina*, Mohd Saad Qodriyah and Yusof Kamisah

Affiliation:

• Department of Pharmacology, Faculty of Medicine, PPUKM, Universiti Kebangsaan Malaysia, Kuala Lumpur,Malaysia

Keywords: Tocopherol, tocotrienol, stress, gastric ulcer, hormones, lipid peroxidation, major organs.

Abstract: Background: Scientific reports had shown that stress is related to numerous pathological changes in the body. These pathological changes can bring about numerous diseases and can significantly cause negative effects in an individual. These include gastric ulcer, liver pathology and neurobehavioral changes. A common pathogenesis in many diseases related to stress involves oxidative damage. Therefore, the administration of antioxidants such as vitamin E is a reasonable therapeutic approach. However, there is conflicting evidence about antioxidant supplementation.

Objective: The aim of this work was to summarize documented reports on the effects of tocopherol and tocotrienol on various pathological changes induced by stress.

Results and Conclusion: This review will reveal the scientific evidence of enteral supplementation of vitamin E in the forms of tocotrienol and tocopherol in animal models of stress. These models mimic the stress endured by critically ill patients in a clinical setting and psychological stress in individuals. Positive outcomes from enteral feeding of vitamin E in reducing the occurrence of stress-induced pathological changes are discussed in this review. These positive findings include their ability to reduced stress-induced gastric ulcers, elevated liver enzymes and improved locomotors activity. Evidences showing tocotrienol and tocopherol effects are not just related to its ability to reduce oxidative stress but also acting on other mechanism, are discussed.

Cite this article as:

Azlina Fahami Nur Mohd *, Qodriyah Saad Mohd and Kamisah Yusof , Tocopherol and Tocotrienol: Therapeutic Potential in Animal Models of Stress, Current Drug Targets 2018; 19 (12) . https://dx.doi.org/10.2174/1389450118666171122130338