An Update of Patents, Preclinical and Clinical Outcomes of Lipid Nanoparticulate Systems

Author(s): Kamla Pathak*, Ravi Shankar, Monika Joshi.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 43 , 2017


Abstract:

Background: Lipid nanoparticles have attracted increased degree of scientific and commercial attention in the last decade. The lipidic nanoparticles have emerged as a potential alternative to other nano-scale systems due to their various advantages over them and also due to overcoming the shortcomings of the already available colloidal systems like liposomes, niosomes and polymeric nanoparticles.

Description: These have been investigated for delivery of macromolecules, genes, siRNA and other therapeutic agents for oral, topical, parenteral administration and target site specific delivery for various diseases like cancer, ocular diseases and brain disorders. The lipid nanoparticles have evolved from SLNs, then NLCs and lipid drug conjugates overcoming any issues related to production and formulation and adding advantages, if any. The current review article focuses on the lipid nanoparticles, their formulation approaches and current advancements in the field through recent clinical trials and patents. This manuscript embodies various patents, preclinical and clinical aspects related to the lipidic nanocarriers.

Conclusion: Over the years the lipidic nanoparticulate systems have evolved as significant carriers for improved therapeutics and in diagnostic field. The large number of patents and preclinical trials in the recent years suggests that these systems will find immense potential in near future.

Keywords: Solid lipid nanoparticles, nanostructured lipid carrier, lipid drug conjugate, patents, clinical trials, polymeric nanoparticles.

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Article Details

VOLUME: 23
ISSUE: 43
Year: 2017
Page: [6602 - 6612]
Pages: 11
DOI: 10.2174/1381612823666171122104216
Price: $58

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