Objective: The objective of the present work was to develop curcumin transdermal films by
solvent evaporation technique using Carboxy polymethylene and Eudragit RS 100 as matrix polymers.
The influence of penetration enhancers: dimethyl sulphoxide (1, 2 and 3% (w/w)), tween 80 (1, 2 and
3% (w/w)) and oleic acid (1, 2 and 3% (w/w)) on the in vitro percutaneous absorption of Curcumin
through the rabbit skin was evaluated.
Methods: Differential scanning calorimetry was used to evaluate the compatibility between the drug
and excipients. All the prepared formulations were evaluated for moisture content, moisture uptake,
flatness, tensile strength, drug content determination and in vitro permeation studies across rabbit skin.
Results: The enhancing effectiveness of the enhancers decreased in the order: Oleic acid > Dimethyl
sulphoxide > Tween 80. Compared to the control formulation 1.3-fold enhancement was observed with
2% tween 80. There were no significant promoting effects at low concentrations of dimethyl sulphoxide;
however, a 1.18-fold increase in Curcumin flux resulted in higher percentage (3%) of dimethyl
sulphoxide. The highest enhancement factor was 1.43 with 2% oleic acid. The skin irritation tests
showed negligible erythema and edema.
Conclusion: The results suggested the possibility of using formulated curcumin films in topical conditions
like wound healing.