Malignant melanoma is a very aggressive form of skin cancer, with increasing rates every year, with
an etiology that derives from the transformation and uncontrolled growth of melanocytes. There are several
treatment options which can be used as unique treatment or combined, depending upon the stage of melanoma
including surgical excision, chemotherapy, immunotherapy, targeted therapy. Plant Kingdom displays an unequalled
potential for the synthesis of highly diversified chemical structures. Although natural compounds are
synthesized in order to help the plant to interact with the environment, a large number of phytochemicals act as
drugs within the human or animal body by activating various biochemical pathways. The study aims to review
another approach in the management of this highly aggressive form of skin cancer, namely the effect of natural
compounds in the chemoprevention of malignant melanoma.
Keywords: Malignant melanoma, natural compounds, chemoprevention, skin cancer, melanocytes, biochemical pathways.
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