This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in
the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved
molecule; it is also an antioxidant and an impressive protector of mitochondrial bioenergetic activity. MLT is
characterized by an ample range of activities, modulating the physiology and molecular biology of the cell. Its
physiological functions relate principally to the interaction of G Protein-Coupled MT1 and MT2 trans-membrane
receptors (GPCRs), a family of guanidine triphosphate binding proteins. MLT has been demonstrated to suppress
the growth of various tumours both, in vivo and in vitro. In this review, we analyze in depth, the antioxidant activity
of melatonin, aiming to illustrate the cancer treatment potential of the molecule, by limiting or reversing the
changes occurring during cancer development and growth.
Keywords: Melatonin, cancer prevention, molecular biology, oxidative stress, antioxidant, cell culture.
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