Title:Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?
VOLUME: 17
Author(s):Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu, Xuelin Wang and Pascal Boireau
Affiliation:The Key Lab of Animal Disease and Public Health/ College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun
Keywords:Trichinella spiralis, tumors, antitumor, tumorigenic, nurse cells,
parasite
Abstract:Conventional therapeutic strategies for tumors have had limited
success, and innovative and more effective approaches to treatment are
urgently required. The ancient idea that various biological, bacterial,
yeast, viral, and parasitic agents can be used as cancer therapeutics has
gradually attracted considerable interest. Certain parasites have been
widely discussed in association with human and animal tumors. Many
researches have provided proofs that Trichinella spiralis (T. spiralis)
possesses antitumor activities. The antitumor effect of T. spiralis was
first described in the 1970s. However, its research has been inconsistent,
and little progress has been made in this field. Therefore, the mechanisms
underlying these inhibitory effects are still unclear, and convincing
evidence of the links between T. spiralis and the prevention or treatment of
tumors from clinical trials is absent. Meanwhile, some other researches also
suggested that T. spiralis may cause or contribute to coinfection with a
tumors. In this review, evidence for T. spiralis to act as a pro- or
antitumorigenic agent is summarized and discussed, in hope of contributing
to a better understanding of the relations between T. spiralis and tumors.
