Objective: The current clinical trial was aimed at evaluating the safety and beneficial effect
of Cassia tora (C. tora) supplementation in healthy adults.
Design: A randomized, double blind, placebo controlled study with a crossover design was done on
60 healthy normal weight adults (age range: 20-55 yrs). The study consisted of 2 treatment phases of
24 weeks each with a washout period of 4 weeks between the phases. 30 subjects randomly allocated
to the ‘Placebo first' group and 30 to ‘C. tora first' group and assigned to receive a dose of C. tora
(330 mg) or matched placebo three times a day. Safety markers were measured at base line and at the
end of both the treatment phases. Body mass index, blood pressure, fasting blood sugar, glycated hemoglobin,
lipid profile and antioxidants were measured at baseline and at every three months interval.
Repeated measures analysis was applied to assess the period and carryover effects of the drug over
placebo on biochemistries.
Results: C. tora supplementation was well tolerated and no apparent changes were observed in safety
markers. The net effect of C. tora in natural units over placebo was 0.83 [0.57, 1.09]- high density
lipoprotein cholesterol; 27.63 [24.39, 30.88]- superoxide dismutase; 0.32 [0.28, 0.36]- catalase; 0.68
[0.56, 0.80]- glutathione peroxidase; 0.25 [0.22, 0.29]- glutathione s-transferase; 0.32 [0.29, 0.36]-
glutathione and -1.08 [-1.63, -0.54]- low density lipoprotein cholesterol.
Conclusion: The findings advocate that C. tora supplementation is safe and beneficial in elevating
high density lipoprotein cholesterol and antioxidants and hence advised for consumption.