Abstract
Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.
Keywords: Muscle atrophy, fibrosis, dystrophy, renin angiotensin system, blocking antibodies, therapy.
Current Protein & Peptide Science
Title:Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions: An Update on Therapeutic Strategies
Volume: 19 Issue: 12
Author(s): Johanna Abrigo, Felipe Simon, Daniel Cabrera, Gonzalo Cordova, Capucine Trollet and Claudio Cabello-Verrugio*
Affiliation:
- Millennium Institute on Immunology and Immunotherapy, Santiago,Chile
Keywords: Muscle atrophy, fibrosis, dystrophy, renin angiotensin system, blocking antibodies, therapy.
Abstract: Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.
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Cite this article as:
Abrigo Johanna , Simon Felipe , Cabrera Daniel , Cordova Gonzalo , Trollet Capucine and Cabello-Verrugio Claudio*, Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions: An Update on Therapeutic Strategies, Current Protein & Peptide Science 2018; 19 (12) . https://dx.doi.org/10.2174/1389203718666171117101916
DOI https://dx.doi.org/10.2174/1389203718666171117101916 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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