Preparation of Nanoparticles Including Antisolvent Drugs by the Combination of Roll Milling and High-pressure Homogenization

Author(s): Seitaro Kamiya*, Maya Yamada , Miki Washino , Kenichiro Nakashima .

Journal Name: Current Nanoscience

Volume 14 , Issue 2 , 2018

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Abstract:

Description: Design methods of nanoparticle formulations are divided into break-down methods and build-up methods. The former is further divided into dry and wet processes. For drug nanoparticle preparations, the wet process is generally employed, and organic solvents are used in most formulations.

Method: In this study, we investigate the preparation of nifedipine (IB) and griseofulvin (GF) nanoparticles without using organic solvent. Both IB and GF nanoparticles, with a mean particle size of approximately 50 nm, were prepared without organic solvent by employing a combination of roll milling and high-pressure homogenization.

Result: The X-ray diffraction peak of the IB and GF samples prepared by roll milling was present at a position (2θ) identical to that of IB and GF crystals, indicating that no peak shift was induced by interaction with phospholipids.

Conclusion: These findings demonstrate that most IB and GF nanoparticles exist as crystals in phospholipids.

Keywords: Nanoparticles, without organic solvent, roll milling, high-pressure homogenization, antisolvent drugs, X-ray diffraction peak, DSC.

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Article Details

VOLUME: 14
ISSUE: 2
Year: 2018
Page: [143 - 147]
Pages: 5
DOI: 10.2174/1573413713666171109155955

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