Background and Objectives: Inflammatory Bowel Disease (IBD) is a group of inflammatory
conditions of the colon and small intestine. Crohn's disease and ulcerative colitis are the principal
types of inflammatory bowel disease. IBD is a complex disease which arises as a result of the interaction
of environmental and genetic factors leading to immunological responses and inflammation in the
intestine. Curcumin, a yellow coloring agent is used as a remedy for the treatment and prevention of
inflammatory disease. Curcumin is safe, non-toxic, and mediates its anti-inflammatory effects through
the down-regulation of inflammatory transcription factors, cytokines, redox status, protein kinases, and
enzymes that all promote inflammation.
Methods: An attempt was made to formulate sustained release pellets of curcumin using Carboxymethyl
Tamarind Seed Polysaccharide (CMTSP). Solid dispersion of curcumin prepared using soluplus
and incorporated into pellets for enhanced solubility and bioavailability. A central composite design
was applied to study the effect of independent variables (amount of microcrystalline cellulose MCC
and CMTSP) on crushing strength and drug release of pellets. In vivo study of solid dispersion loaded
pellets revealed the presence of more amount of drug in plasma than pure drug loaded pellets.
Result: Dissolution and absorption of curcumin were found to be increased by 1.5 and 2 fold, respectively.
Conclusion: Carboxymethyl tamarind seed polysaccharide can be used successfully for colon targeted
drug delivery system in the form of pellets. The percent permeability of pellets prepared by using solid
dispersion was found to be more than pellets prepared by using pure drug. Curcumin has an advantageous
safety profile as well as low relativecost, making it an attractive option for IBD patients.