Current Surgical Options for Patients with Epilepsy

Author(s): Fahid T. Rasul, Jarnail Bal, Erlick A. Pereira, Martin Tisdall, Marios Themistocleous, Nikolaos Haliasos*.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 42 , 2017

Abstract:

Surgery for epilepsy dates back to 1886 and has undergone significant developments. Today it is considered a key treatment modality in patients who are resistant to pharmacological intervention. It improves seizure control, cognition and quality of life. New technologies, advances in surgical technique and progress in scientific research underlie the expansion of surgery in epilepsy treatment. Effectiveness of surgical treatment depends on several factors including the type of epilepsy, the underlying pathology and the localisation of the epileptogenic zone. Timely referral to an experienced epilepsy surgery centre is important to allow the greatest chance of seizure control and to minimise associated morbidity and mortality. Following referral, patients undergo thorough presurgical investigation to evaluate their suitability for surgery. The commonest form of epilepsy treated by surgery is mesial temporal lobe sclerosis and there is Class I evidence for the medium-term efficacy of temporal lobe resection from two randomised control trials. Various other forms of epilepsy are now considered for resective and neuromodulatory surgical intervention due to favourable results. In this article, the authors review the current status of surgical treatment for epilepsy including the presurgical evaluation of patients, surgical techniques and the future directions in epilepsy surgery.

Keywords: Epilepsy, surgery, temporal lobe, deep brain stimulation, vagal nerve stimulation, seizure.

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Article Details

VOLUME: 23
ISSUE: 42
Year: 2017
Page: [6508 - 6523]
Pages: 16
DOI: 10.2174/1381612823666171031101839
Price: $58

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