Background: Recently, a great interest has been paid to the development of hybrid proteininorganic
nanoparticles (NPs) for tissue engineering applications to combine the merits of both inorganic
and protein nanocarriers.
Objective: This short review primarily discusses the most important advances in the application of the
hybrids of proteins (gelatin, zein, silk fibroin,….etc) with inorganic NPs (calcium phosphate NPs, cadmium
QDs, carbon nanotubes,…etc) in tissue engineering.
Results: Various strategies that have been utilized for the preparation of protein-functionalized inorganic
NPs are discussed. Nanocomposite films, electrospun nanofibrous scaffolds, nanostructured colloidal
composite gels and nanocomposite lyophilized sponges are among the most common platforms
of protein-inorganic nanohybrid formulations used in regenerative medicine.
Conclusion: protein-inorganic nanohybrids could serve as promising platforms for different biomedical
applications including bone and cartilage tissue regeneration, imaging of engineered tissues, development
of antithrombogenic implant biomaterials and anti-bacterial wound dressing as well.