Luminescence bioimaging is widely used for noninvasive monitoring of biological
targets in real-time with high temporal and spatial resolution. For efficient bioimaging
in vivo, it is essential to develop smart organic dye platforms. Fluorescein (FL), a
traditional dye, has been widely used in the biological and clinical studies. However, visible
excitation and emission limited their further application for in vivo bioimaging. Nearinfrared
(NIR) dyes display advantages of bioimaging because of their minimum absorption
and photo-damage to biological samples, as well as deep tissue penetration and low
auto-luminescence from background in the living system. Thus, some great developments
of near-infrared fluorescein-inspired dyes have emerged for bioapplication in vitro and in
vivo. In this review, we highlight the advances in the development of the near-infrared
chemodosimeters for detection and bioimaging based on the modification of fluoresceininspired
dyes naphtho-fluorescein (NPF) and cyanine-fluorescein (Cy-FL).
Keywords: Near Infrared, naphtho-fluorescein, cyanine-fluorescein, luminescence, chemodosimeter, bioimaging.
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