Synthesis of Isoxazolidines, Isoxazolines and Isoxazoles from O-Unsaturated Alkoxyamines

Author(s): Julien Escudero, Veronique Bellosta, Janine Cossy*.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 5 , 2018

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Abstract:

O-Unsaturated alkoxyamines are versatile compounds that can be cyclized to heterocyclic 5-membered rings by using onium ions, transition metals, Brønsted and Lewis acids. O-Allylic and O-homoallylic alkoxyamines can be transformed to isoxazolidines, O-allenyl alkoxyamines to isoxazolidines as well as to 2-isoxazolines and O-alkynyl alkoxyamines to 2- or 3-isoxazolines as well as to isoxazoles.

Keywords: Alkoxyamine, hydroxylamine, isoxazolidine, isoxazoline, isoxazole, cyclization, synthesis, review.

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Article Details

VOLUME: 15
ISSUE: 5
Year: 2018
Page: [365 - 374]
Pages: 10
DOI: 10.2174/1570178614666171023161721
Price: $65

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