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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Review Article

Synthesis of Isoxazolidines, Isoxazolines and Isoxazoles from O-Unsaturated Alkoxyamines

Author(s): Julien Escudero, Veronique Bellosta and Janine Cossy*

Volume 15, Issue 5, 2018

Page: [365 - 374] Pages: 10

DOI: 10.2174/1570178614666171023161721

Price: $65

Abstract

O-Unsaturated alkoxyamines are versatile compounds that can be cyclized to heterocyclic 5-membered rings by using onium ions, transition metals, Brønsted and Lewis acids. O-Allylic and O-homoallylic alkoxyamines can be transformed to isoxazolidines, O-allenyl alkoxyamines to isoxazolidines as well as to 2-isoxazolines and O-alkynyl alkoxyamines to 2- or 3-isoxazolines as well as to isoxazoles.

Keywords: Alkoxyamine, hydroxylamine, isoxazolidine, isoxazoline, isoxazole, cyclization, synthesis, review.

Graphical Abstract

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