Abstract
Background: Common childhood neuropsychiatric disorders are treated with multiple categories of psycho-active agents. Adverse side effects of psychotropic pharmacotherapeutics range from expected neuro-psychiatric changes to allergic reactions and immunologic abnormalities.
Objective: This review focuses on the immune system effects of common categories of medications used to treat neuro-psychiatric and behavioral disorders.
Method: Narrative review of literature using PubMed database up to May 10, 2017.
Results: Multiple neuro- and psycho-tropic medication classes are found to influence the function of the immune system in various ways, both in the direction of immune suppression and immune stimulation.
Conclusion: Immunologic activity of these medications in the frame-work of now wellestablished role of inflammation in neuro-psychiatric diseases should continue to be defined. At the same time, clinicians are advised to pay attention to potentially detrimental immune suppression that may be associated with some of these medications, and consider iatrogenic etiology in patients presenting with undue susceptibility to infection.
Keywords: Inflammation, immune, psychotropic, psychopharmacology, psychiatric, immunodeficiency.
Current Psychopharmacology
Title:Immunologic Effects of Psychotropic Pharmaco-Therapeutics
Volume: 7
Author(s): Andrey Leonov*, Donald E. Greydanus and H.C. Athens
Affiliation:
- Western Michigan University, Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, MI 49008-1284,United States
Keywords: Inflammation, immune, psychotropic, psychopharmacology, psychiatric, immunodeficiency.
Abstract: Background: Common childhood neuropsychiatric disorders are treated with multiple categories of psycho-active agents. Adverse side effects of psychotropic pharmacotherapeutics range from expected neuro-psychiatric changes to allergic reactions and immunologic abnormalities.
Objective: This review focuses on the immune system effects of common categories of medications used to treat neuro-psychiatric and behavioral disorders.
Method: Narrative review of literature using PubMed database up to May 10, 2017.
Results: Multiple neuro- and psycho-tropic medication classes are found to influence the function of the immune system in various ways, both in the direction of immune suppression and immune stimulation.
Conclusion: Immunologic activity of these medications in the frame-work of now wellestablished role of inflammation in neuro-psychiatric diseases should continue to be defined. At the same time, clinicians are advised to pay attention to potentially detrimental immune suppression that may be associated with some of these medications, and consider iatrogenic etiology in patients presenting with undue susceptibility to infection.
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Cite this article as:
Leonov Andrey *, Greydanus E. Donald and Athens H.C. , Immunologic Effects of Psychotropic Pharmaco-Therapeutics, Current Psychopharmacology 2018; 7 (1) . https://dx.doi.org/10.2174/2211556006666171019155320
DOI https://dx.doi.org/10.2174/2211556006666171019155320 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
Call for Papers in Thematic Issues
Breakthroughs in drug design, development and delivery system for the management of neuro-psychiatric disorders
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. This proposal describes the ...read more
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