Background: Chronic diseases are becoming more serious and widely spreading and this carries
a heavy burden on doctors to deal with such patients. Although many of these diseases can be treated
by bacteriophages, the situation is significantly dangerous in patients having concomitant more than
one chronic disease, where conflicts between phages used in treating these diseases are very closer to
Method: This research paper presents a method to detecting the Bacteriophage-Bacteriophage Interaction.
This method is implemented based on Domain-Domain Interactions model and it was used to infer
Domain-Domain Interactions between the bacteriophages injected in the human body at the same time.
Results: By testing the method over bacteriophages that are used to treat tuberculosis, salmonella and
virulent E.coli, many interactions have been inferred and detected between these bacteriophages. Several
effects were detected for the resulted interactions such as: playing a role in DNA repair such as nonhomologous
end joining, playing a role in DNA replication, playing a role in the interaction between the
immune system and the tumor cells and playing a role in the stiff man syndrome. We revised all patents
relating to bacteriophage bacteriophage interactions and phage therapy.
Conclusion: The proposed method is developed to help doctors to realize the effect of simultaneously
injecting different bacteriophages into the human body to treat different diseases.