Phospholipid-based Immobilized Artificial Membrane (IAM) Chromatography: A Powerful Tool to Model Drug Distribution Processes

Author(s): Anna W. Sobanska*, Elzbieta Brzezinska.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 44 , 2017


Abstract:

A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes, blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography are presented.

Keywords: IAM chromatography, blood-brain barrier, skin permeability, oral bioavailability.

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Article Details

VOLUME: 23
ISSUE: 44
Year: 2017
Page: [6784 - 6794]
Pages: 11
DOI: 10.2174/1381612823666171018114331
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