A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug
discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes,
blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared
to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine
based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography
Keywords: IAM chromatography, blood-brain barrier, skin permeability, oral bioavailability.
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