For many years, colchicine has been used for therapeutic purposes and has
been given considerable attention because of its association with tubulin and inhibition
of small tubular polymerization. Colchicine is an alkaloid extracted from the
colchicum autumnale plant, having molecular formula C22H25NO6, and consists of
three rings. Many studies are concerned with structural changes in order to increase
their pharmacological effectiveness and reduce the side effects of toxicity arising
from it. The therapeutic use of colchicine has been mainly documented in Gout, Familial
Mediterranean Fever, and many other diseases such as atrial fibrillation. This
review summarizes the history of chemical structure of colchicine and presents some
of its analogues. Furthermore, it shows binding mechanism with target protein when
colchicine is used as a therapeutic drug, and gives a light spot on some studies that
discuss the safe use of colchicine.
Keywords: Colchicine, analogues of colchicine, familial Mediterranean fever, gout, tubulin, atrial fibrillation.
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