Background: Blood brain barrier and Alzheimer’s disease are interrelated. This interrelation
is detected by physicochemical methods, pharmacological and electrophysiological analyses.
Nature of the phenomenon is extremely complex. The description of this interrelation in mathematical
terms is a very important task.
Objective: The systematization of facts, which are described in the literature and related to interaction
between processes, which influence Alzheimer's disease and blood brain barrier is the subject
of this work. In addition, establishing of correlations between molecular features and endpoints,
which are related to the treatment of Alzheimer's disease and blood brain barrier using the CORAL
software are subjects of this work.
Methods: The information on logically structured analysis is available in the literature and building
up quantitative structure – activity relationships (QSARs) by the Monte Carlo method has been
used to solve the task of systematization of facts related to the "treatment of Alzheimer's disease vs.
blood brain barrier".
Results: Comparison of agreements and disagreements of the available published papers together
with the statistical quality of built up QSARs are results of this work.
Conclusion: The facts from published papers and technical details of QSAR built up in this study
give possibility to formulate the following rules: (i) there are molecular alerts, which are promoters
to increase blood brain barrier and therapeutic activity of anti-Alzheimer disease agents; (ii) there
are molecular alerts, which contradict each other.