Abstract
In the last four decades, the several classes of diuretics, currently available for clinical use, have been the first line option for the therapy of widespread cardiovascular and non-cardiovascular diseases. Diuretic drugs generally exhibit an overall favourable risk/benefit balance. However, they are not devoid of side effects. In particular, all the classes of diuretics cause alteration of potassium homeostasis.
In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors. This novel class is expected to promote diuretic activity comparable to (or even higher than) that provided by the most effective drugs used in clinics (such as furosemide), with limited effects on potassium homeostasis.
In this review, the physio-pharmacological roles of ROMK channels in the renal function are reported, along with the most representative molecules which have been currently developed as ROMK inhibitors.
Keywords: Renal, medullary potassium channel, diuretic drugs, homeostasis, ROMK.
Current Medicinal Chemistry
Title:The Renal Outer Medullary Potassium Channel (ROMK): An Intriguing Pharmacological Target for an Innovative Class of Diuretic Drugs
Volume: 25 Issue: 23
Author(s): Vincenzo Calderone*, Alma Martelli, Eugenia Piragine, Valentina Citi, Lara Testai and Maria C. Breschi
Affiliation:
- Dipartimento di Farmacia, Università di Pisa, Pisa,Italy
Keywords: Renal, medullary potassium channel, diuretic drugs, homeostasis, ROMK.
Abstract: In the last four decades, the several classes of diuretics, currently available for clinical use, have been the first line option for the therapy of widespread cardiovascular and non-cardiovascular diseases. Diuretic drugs generally exhibit an overall favourable risk/benefit balance. However, they are not devoid of side effects. In particular, all the classes of diuretics cause alteration of potassium homeostasis.
In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors. This novel class is expected to promote diuretic activity comparable to (or even higher than) that provided by the most effective drugs used in clinics (such as furosemide), with limited effects on potassium homeostasis.
In this review, the physio-pharmacological roles of ROMK channels in the renal function are reported, along with the most representative molecules which have been currently developed as ROMK inhibitors.
Export Options
About this article
Cite this article as:
Calderone Vincenzo *, Martelli Alma , Piragine Eugenia , Citi Valentina , Testai Lara and Breschi C. Maria , The Renal Outer Medullary Potassium Channel (ROMK): An Intriguing Pharmacological Target for an Innovative Class of Diuretic Drugs, Current Medicinal Chemistry 2018; 25 (23) . https://dx.doi.org/10.2174/0929867324666171012120937
DOI https://dx.doi.org/10.2174/0929867324666171012120937 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Limited Hypotensive Effect of Sildenafil in a High-Risk Population: A Preliminary Report
Current Drug Safety Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer
Current Pharmaceutical Design Wearable and Implantable Wireless Body Area Networks
Recent Patents on Electrical Engineering Therapeutic Applications of Calcium Metabolism Modulation in Heart Disease
Medicinal Chemistry Myostatin in the Pathophysiology of Skeletal Muscle
Current Genomics Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
Current Drug Safety Lipid Peroxidation End-Products as Modulators of Catabolic and Inflammatory Responses in Arthritis: A Review
Current Rheumatology Reviews Experimental Model Considerations for the Study of Protein-Energy Malnutrition Co-Existing with Ischemic Brain Injury
Current Neurovascular Research Endocannabinoids in Liver Disease and Hepatic Encephalopathy
Current Pharmaceutical Design Thrombus Extraction Catheters vs. Angiojet Rheolytic Thrombectomy in Thrombotic Lesions/SV Grafts
Current Cardiology Reviews Urocortins: Putative Role in Cardiovascular Disease
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Brain Excitatory/Inhibitory Circuits Cross-Talking with Chromogranin A During Hypertensive and Hibernating States
Current Medicinal Chemistry Advances in Development of Phosphatidylinositol 3-Kinase Inhibitors
Current Medicinal Chemistry Ultrasound Diagnosis of Soft Tissue Vascular Malformations and Tumours
Current Medical Imaging Small Animal Computed Tomography Imaging
Current Medical Imaging Editorial (Thematic Issue: Cardiac Imaging in the Diagnosis of Coronary Artery Disease: A Comprehensive Overview of Various Imaging Modalities)
Current Medical Imaging Editorial (Thematic Issue: Salt Sensitive Hypertension: Mechanisms, Management, Prognosis and Treatment)
Current Hypertension Reviews The HCMV Chemokine Receptor US28 is a Potential Target in Vascular Disease
Current Drug Targets - Infectious Disorders A Constrained Probabilistic Matrix Decomposition Method for Predicting miRNA-disease Associations
Current Bioinformatics Cell Senescence in Cardiac Repair and Failure
Current Stem Cell Research & Therapy