Background: Application of microwave irradiation to heterogeneous catalysis has not been
explored intensively due to arching phenomena of metals-supported catalysts in presence of flammable
solvents. Hence, solvent free organic microwave synthesis has attracted great interests because of
high efficiency, shorter reaction times and eco-friendly nature.
Methods: This is the report of an efficient and expeditious green protocol for SNAr reaction of 2-
bromo-3, 5-dinitrothiophene with amines and thiophenols using microwave heating. The solvent-free,
chromatography-free method is highly sustainable along with the recyclability point of the solid
support simple neutral Al2O3.
Results: Approximately 100% conversion takes place just only in 2-3 min under microwave irradiation
Conclusion: Several N-substituted 3, 5-dinitrothiophene-2-amine and S-substituted 3, 5-dinitro-2-sulfanylthiophene
derivatives have been synthesized with good to excellent yields within very short time
in environmentally benign manner. The synthesized products show very interesting morphological
feature (microporous tube) towards privileged nanotechnology. Another mentionable thing is that the
products are fully organic microporous tubes whose synthesis is really challenging.