Ebola virus has caused 26 outbreaks in 10 different countries since its identification
in 1976, making it one of the deadliest emerging viral pathogens. The most recent
outbreak in West Africa from 2014-16 was the deadliest yet and culminated in 11,310
deaths out of 28,616 confirmed cases. Currently, there are no FDA-approved therapeutics
or vaccines to treat Ebola virus infections. The slow development of effective vaccines
combined with the severity of past outbreaks emphasizes the need to accelerate research
into understanding the virus lifecycle and the development of therapeutics for post exposure
treatment. Here we present a summary of the major findings on the Ebola virus replication
cycle and the therapeutic approaches explored to treat this devastating disease. The
major focus of this review is on small molecule inhibitors.
Keywords: Ebola virus, viral pathogens, ebolavirus genus, ebola virus entry mechanisms, transcription and replication
mechanisms, marburg virus.
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