Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora

Author(s): Rita Morigi, Beatrice Vitali, Cecilia Prata, Rogers A.N. Palomino, Alessandra Graziadio, Alessandra Locatelli, Mirella Rambaldi, Alberto Leoni*.

Journal Name: Medicinal Chemistry

Volume 14 , Issue 3 , 2018

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Abstract:

Background: Fused five-membered heterocyclic rings containing bridgehead nitrogen atom are particularly versatile in the field of medicinal chemistry because of their different biological activities. Among them, the imidazo[2,1-b]thiazole is an attractive fused heterocyclic core that has been extensively studied.

Objective: The aim of the current study was to study the therapeutic applications of imidazo[2,1- b]thiazole derivatives as antimicrobial agents for the treatment of genitourinary infections.

Method: A traditional synthetic methodology was involved to obtain a small series of imidazothiazole derivatives.

Results: Herein, we report the antimicrobial activity of the imidazo[2,1-b]thiazole or imidazo[2,1- b]thiazolidine derivatives against selected fungi, Gram-positive and Gram-negative bacteria. Moreover, experiments were carried out to investigate the interference towards the endogenous microbiota.

Conclusion: The most interesting of the series are the thiocyano derivatives (19, 23) showing a good profile for the treatment of genitourinary infections: a spectrum of activity covering both bacteria and fungi together with a reduced impact versus critical lines of Lactobacillus exerting defense against pathogens.

Keywords: Ampicillin, imidazo[2, 1-b]thiazole, urogenital pathogens, bifidobacteria, lactobacilli, antiproliferative effects.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2018
Page: [311 - 319]
Pages: 9
DOI: 10.2174/1573406413666171010110819
Price: $58

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