Development of Drug Targeting and Delivery in Cervical Cancer

Author(s): Urvashi Aggarwal, Amit Kumar Goyal, Goutam Rath*.

Journal Name: Current Cancer Drug Targets

Volume 18 , Issue 8 , 2018

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Abstract:

Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer include chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from the treatment and improve the quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery. In addition to that addressing the anatomical significance of cervical cancer, various local drug delivery strategies for the cancer treatment are introduced like: gels, nanoparticles, polymeric films, rods and wafers, lipid based nanocarrier. Localized drug delivery systems allow passive drug targeting results in high drug concentration at the target site. Further they can be tailor made to achieve both sustained and controlled release behavior, substantially improving therapeutic outcomes and minimizing side effects. This review summarizes the meaningful advances in drug delivery strategies to treat cervical cancer.

Keywords: Cervical cancer, drug delivery system, drug targeting, localized delivery, nanocarriers, parenteral route.

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Article Details

VOLUME: 18
ISSUE: 8
Year: 2018
Page: [792 - 806]
Pages: 15
DOI: 10.2174/1568009617666171009165105
Price: $58

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