Background: Chemotherapy, the predominant cancer treatment modality, suffers from
elimination in renal and hepatic systems causing reduced bioavailability and increased toxicity leading
to harmful side effects. Targeted release of formulations encapsulated in protective biocompatible
polymer or polymer-lipid microbubbles can improve bioavailability and potency while reducing
systemic toxicity, resulting in a higher therapeutic index.
Objective: Double emulsion, the most common method for microbubble fabrication suffers from low
encapsulation efficiency and wide size distributions. In this concise article, we analyze the emergent
coaxial electrospray technique vis-à-vis established double emulsion methods to manufacture biocompatible
polymer microbubbles for targeted drug delivery systems.
Method: Specifically, we investigate size, morphology, and encapsulation efficiencies of microbubbles
fabricated using double emulsion and coaxial electrospray techniques.
Results: We found that microbubbles produced via coaxial electrospray displayed higher encapsulation
efficiency and a narrower size distribution.
Conclusion: Coaxial electrospray is a promising technology with considerably improved size distribution
and encapsulation efficiency; however, reproducibility across facilities and scale remain challenging.